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Laboratory Medicine Update - July 23, 2008

University of Virginia Health System

Medical Laboratories

"Quality You Expect, Service You Deserve"


July 23, 2008


2007 Antimicrobial Susceptibility Profiles

Antimicrobial Susceptibility Profiles for 2007 are available in card form from the Microbiology office or as E-mail attachments.  Please call 4-8059 and request the number you would like or send an e-mail to Sandy Getchell-White or William Kuruzovich in Outlook to request them as e-mail attachments.


Updates from the Special Coagulation Testing Laboratory

The special coagulation laboratory has changed instrumentation with new reference intervals for the following assays:

Protein S, Protein C, Plasminogen, Plasminogen Inhibitor, von Willebrand's Antigen, Factor Assays, Modified Russel Viper Venom Time (mRVVT) and the new Lupus Anticoagulant assay, Silica Clotting Time 

The Silica Clotting Time will replace the PTTLA assay in the battery of tests to rule out Lupus Anticoagulant.

  The new reference intervals for the Silica Clotting Time are as follows:

   Silica Clotting Time Screen = 22.9 - 53.2 seconds

   Silica Clotting Time Confirm = 27.6 - 47.9 seconds

   Silica Clotting Time Ratio =     < 1.3

Use the Lupus Anticoagulant Code in MIS and eCare to access the entire panel. This order set will include Modified Russell Viper Venom Time (mRVVT), Silica Clotting Time and Staclot LA.  Silica Clotting Time and mRVVT screens will always be performed.  Staclot LA will also be performed as a confirmatory test unless both the Silica Clotting Time and mRVVT are consistent with the presence of a Lupus Anticoagulant.  

As with all reference interval updates, the changes will be reflected on all patient reports and in the electronic medical record.

For any questions, please contact the Special Coagulation Laboratory at 434-924-8007 or page the Clinical Pathology Resident at 1663.

How to Request "Turning Off" Automatically Printed Laboratory Reports

In an effort to save both paper and expenses, the Medical Laboratories can inactivate printed laboratory reports for those areas obtaining laboratory results electronically.  Clinical Pathology reports (Chemistry, Hematology, etc.) are routed by patient location and can be inactivated at the request of the manager of that particular area.  Anatomic Pathology reports (Surgical Pathology, Cytology, etc.) are routed by physician and can be inactivated at the request of that physician.  Please note that a request to stop Anatomic Pathology reports for an individual physician may include locations where electronic report retrieval is either not available or not utilized. 


Double Stranded DNA Method Change

The method for performing dsDNA analysis will change from indirect immunofluorescence to multiplexing on August 1, 2008.  The reporting format will also change from qualitative to quantitation with results reported in IU/mL.   Results less than or equal to 4 IU/mL are considered normal (negative).  Results between 5 and 9 IU/mL are considered indeterminate.  Results equal to or greater than 10 IU/mL are considered abnormal (positive).  The reporting range is from 1 to 300 IU/mL.